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Bottle of 30 tablets. 20mg of Tamoxifen per tab. Tamoxifen citrate is used to treat breast cancer, as well as to prevent and treat gynecomastia in men.
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Tamoxifen citrate competes over the estrogen receptors in target cells, this way making estrogen ineffective. This action reduces estrogen-sensitive tumours in women, and breast, or other feminine tissues (gynecomastia), in men.
Nolvadex is a non-steroidal compound which competitively inhibits estrogen receptors in its target organs (and/or estrogen-sensitive tumors); when present in cell nuclei, tamoxifen citrate-receptor-co-factor complexes prevent hypertrophy (overgrowth) of estrogen-sensitive cells.
Once in the body, tamoxifen citrate is broken down into compounds that bind estrogen receptors without activating them: estrogen activity is blocked (reduced negative feedback inhibition) in pituitary and hypothalamus, allowing this drug to increase follicle-stimulating hormone and luteinizing hormone in the male body.
Doctor’s directions or prescription label should be followed at all times. Prescribed dose or dosing regimen should not be altered without consulting a doctor first. Dosing regimen depends on the severity of condition; long term treatment course (approximately 2 years) is advised.
Tamoxifen citrate can be used either in a single dose or divided in two, taking one half in the morning and one in the evening; can be taken with or without food but with plenty (full glass) of water; do not chew or crush.
Tamoxifen citrate is contraindicated in pregnant and breastfeeding women, in patients allergic to it, women undergoing coumarin-type anticoagulant therapy, and with history of pulmonary ebolus;
Women should not become pregnant while taking tamoxifen citrate. Caution is advised in patients with any form of eye disease, hyperlipidemia, leukopenia, thrombocytopenia, hyperkalemia, severe thrombophlebitis and in those with history of thromboembolism.
Side effects are unexpected but some people can experience nausea, hot flashes, weight gain, vomiting. On rare occasions, cough, fatigue, bone pain, fluid retention, cataracts, and depression.
In women - menstrual irregularities, abnormal vaginal bleeding, and change in vaginal discharge can occur.
Both Genders: swelling of extremities, loss of libido, weight loss, joint weakness and mood changes also possible.
Store in a dry place at 20-25 C (68-77 F).
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